Chimerism and Tolerance Induction in Kidney Transplantation
نویسندگان
چکیده
منابع مشابه
Chimerism and tolerance induction in kidney transplantation.
Chimerism is a state in which bone marrow hematopoietic stem cells from two genetically different animals coexist. To date, the approach has been used successfully to induce the state of immunologic tolerance in the animal models and is now being evaluated in clinical trials of both HLA-identical and HLA-mismatched living-donor kidney transplant recipients in some transplant centers with varyin...
متن کاملRelationship between chimerism and tolerance in a kidney transplantation model.
The persistence of donor leukocytes in recipients of organ allografts has been associated with long-term graft acceptance. However, it remains unclear whether this peripheral donor cell microchimerism plays an active role in graft acceptance or is simply a consequence of the maintenance of sufficient immunosuppression to avoid rejection. A model of kidney transplantation between swine leukocyte...
متن کاملChimerism and tolerance in transplantation.
Studies in experimental models (1953-1956) demonstrated that acquired donor-specific allotolerance in immunologically immature or irradiated animals is strongly associated with donor leukocyte chimerism. Bone marrow transplantation in immune-deficient or cytoablated human recipients was a logical extension (1968). In contrast, clinical (1959) and then experimental organ transplantation was syst...
متن کاملXenobiotics, chimerism and the induction of tolerance following organ transplantation.
The successful results seen after organ transplantation are largely attributable to the potency and specificity of modern immunosuppressive agents. Although drug-free unresponsiveness to graft alloantigens has not been routinely achieved in clinical practice, recent appreciation of the importance of cell chimerism, which develops after the migration from donor to host of leukocytes contained in...
متن کاملTolerance and chimerism in liver transplantation.
Advances in immunosuppressive therapy have greatly impacted on the successful outcome of organ –and most particularly liver– transplantation. With the introduction of new immunosuppressants the incidence of acute rejection has considerably decreased, and transplanted patient survival is now 83% and 70% after 1 and 5 years, respectively (1). However, toxicity associated with these drugs is signi...
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ژورنال
عنوان ژورنال: Nephron
سال: 2014
ISSN: 1660-8151,2235-3186
DOI: 10.1159/000369311